| Title | The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis. | | Author(s) | Anastasilakis AD, Polyzos SA, Avramidis A, Toulis KA, Papatheodorou A, Terpos E | | Institution | Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece. | | Source | Clin Endocrinol (Oxf) 2009 Oct 15. | | Abstract | SUMMARY
Objective. Parathyroid hormone increases the differentiation of osteoblast precursors through canonical wingless (Wnt) signalling, resulting in an osteoanabolic effect. We aimed to evaluate serum levels of the Wnt-inhibitor Dickkopf-1 (Dkk-1) in postmenopausal women with established osteoporosis and their changes with teriparatide (TPTD - human recombinant PTH 1-34). Design and patients. Thirty-one postmenopausal Caucasian women with established osteoporosis (mean age 66.3+/-1.4 years) received daily injections of 20 mug TPTD for 18 months. Follow-up was continued for another six months after treatment discontinuation (totally 24 months). Measurements. Serum samples for total calcium (Ca), intact PTH (iPTH), bone-specific alkaline phosphatase (BSAP), C-terminal cross-linking telopeptide of type 1 collagen (CTx) and Dkk-1 were obtained at baseline, 6 months, 18 months and 24 months after TPTD initiation. Lumbar spine bone mineral density (BMD) was measured before and after 18 months of TPTD treatment. Sixteen age- and gender-matched healthy controls were also analyzed at baseline.
Results. Serum Dkk-1 levels at baseline were significantly higher in osteoporotic women compared with controls (p<0.002). Dkk-1 increased significantly during TPTD administration (p<0.044) and decreased to baseline six months after TPTD discontinuation. Dkk-1 change was positively correlated to Ca (r=0.530, p=0.004) and negatively correlated to iPTH change (r=-0.398, p=0.040). There was no correlation between Dkk-1 and BMD changes.
Conclusions. Our data suggest that Dkk-1 levels are increased in women with postmenopausal osteoporosis. TPTD therapy results in further increase of Dkk-1 that may be compensative to TPTD-induced enhanced Wnt-signalling. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19832854 |
|
