| Title | The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. | | Author(s) | Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, Mulder I, Lan A, Bridonneau C, Rochet V, Pisi A, De Paepe M, Brandi G, Eberl G, Snel J, Kelly D, Cerf-Bensussan N | | Institution | INRA, U910, Unité Ecologie et Physiologie du Système Digestif, Domaine de Vilvert, 78350 Jouy-en-Josas, France; INSERM, U793, Université Paris Descartes, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. | | Source | Immunity 2009 Oct 16; 31(4):677-89. | | Abstract | Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19833089 |
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