| Title | Developmental trajectories in early hematopoiesis. | | Author(s) | Murre C | | Institution | Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA. murre@biomail.ucsd.edu | | Source | Genes Dev 2009 Oct 15; 23(20):2366-70. | | MeSH | Animals
B-Lymphocytes
Cell Differentiation
Gene Expression Regulation, Developmental
Hematopoiesis
Mice
T-Lymphocytes
Transcription Factors
| | Abstract | The paths that hematopoietic stem cells take to develop from multipotent, self-renewing cells into committed lymphocytes has been a topic of debate for some time. During early hematopoiesis, multiple branchpoints have been described in which progeny cells segregate into cell lineages with distinct developmental potentials. In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel. | | Language | eng | | Pub Type(s) | Comment
Journal Article
| | PubMed ID | 19833763 |
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