| Title | Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. | | Author(s) | Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL | | Institution | Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. minlay@stanford.edu | | Source | Genes Dev 2009 Oct 15; 23(20):2376-81. | | MeSH | Animals
Antigens, Ly
B-Lymphocytes
Cell Differentiation
Cells, Cultured
Gene Expression Regulation, Developmental
Lymphoid Progenitor Cells
Mice
Mice, Inbred C57BL
T-Lymphocytes
| | Abstract | Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have little myeloid potential in vivo. However, some studies claim that the upstream lymphoid-primed multipotent progenitor (LMPP) is the thymic seeding population, and suggest that CLPs are primarily B-cell-restricted. To identify surface proteins that distinguish functional CLPs from B-cell progenitors, we used a new computational method of Mining Developmentally Regulated Genes (MiDReG). We identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19833765 |
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