Fast synaptic subcortical control of hippocampal circuits. Science (New York, N.Y.) [Science] Journal article

Title	Fast synaptic subcortical control of hippocampal circuits.
Author(s)	Varga V, Losonczy A, Zemelman BV, Borhegyi Z, Nyiri G, Domonkos A, Hangya B, Holderith N, Magee JC, Freund TF
Institution	Institute of Experimental Medicine, Budapest 1083, Hungary. vargav@koki.hu
Source	Science 2009 Oct 16; 326(5951):449-53.
MeSH	Animals Electric Stimulation Excitatory Postsynaptic Potentials Glutamic Acid Hippocampus Inhibitory Postsynaptic Potentials Interneurons Mice Neural Inhibition Neural Pathways Neurons, Afferent Patch-Clamp Techniques Photic Stimulation Raphe Nuclei Rats Rats, Sprague-Dawley Serotonin Synapses Synaptic Potentials
Abstract	Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.
Language	eng
Pub Type(s)	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
PubMed ID	19833972

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