| Title | C-Reactive Protein Gene Variant and the Human Left Ventricular Growth Response to Exercise: Data from the LARGE Heart Study. | | Author(s) | Mann JJ, Payne1 JR, Shah T, Pennell DJ, Humphries SE, Montgomery HE | | Institution | 1Centre for Cardiovascular Genetics, BHF Laboratories, Royal Free & University College Medical School, 5 University Street, London, UK 2Centre for Clinical Pharmacology in the Department of Medicine at UCL 3Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK 4Institute for Human Health and Performance, Ground Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, Archway, London N19 5LW *All authors contributed equally. | | Source | J Cardiovasc Pharmacol 2009 Oct 9. | | Abstract | AIMS:: Increased levels of C-reactive protein (CRP) are associated with left ventricular (LV) hypertrophy. This association may be causal (either directly, or indirectly), or simply a confounder resulting from the recognised relationship between CRP and vascular disease. We attempted to clarify this issue, by assessing the association of a variant of the CRP gene with exercise-induced left ventricular hypertrophy in young healthy males: homozygosity for the T (rather than C) allele of the CRP +1444C>T gene variant is associated with serum CRP levels which are 0.68mg/l higher than carriers of the C-allele.
METHODS AND RESULTS:: LV mass was measured using cardiovascular magnetic resonance (CMR) in 301 Army recruits before and after an identical 12-week physical training program. Subjects were genotyped for the CRP +1444C>T gene variant. LV mass was 164.25 +/- 24.52g at entry, and increased with training (+3.77 +/- 10.77g). This increase was greatest amongst those homozygous for the rare T allele (+8.17 +/- 12.09 vs. +3.37 +/- 10.58 for TT genotype vs. C-allele carriers respectively, p = 0.033).
CONCLUSIONS:: CRP genotype is associated with a greater LV growth to exercise, supporting a causal association between CRP and LV growth. Whether such an association might be directly mediated, or results from alterations in phenotypes which themselves drive LV growth (for instance, altered arterial compliance) is not clear. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19834334 |
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