| Title | A General and Efficient Approach to Aryl Thiols: CuI-Catalyzed Coupling of Aryl Iodides with Sulfur and Subsequent Reduction. | | Author(s) | Jiang Y, Qin Y, Xie S, Zhang X, Dong J, Ma D | | Institution | State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, and Shenyang Pharmaceutical University, 103 Wenhua Lu, Shenyang 110016, China. | | Source | Org Lett 2009 Oct 16. | | Abstract | A CuI-catalyzed coupling reaction of aryl iodides and sulfur powder takes place in the presence of K(2)CO(3) at 90 degrees C. The coupling mixture is directly treated with NaBH(4) or triphenylphosphine to afford aryl thiols in good to excellent yields. A wide range of substituted aryl thiols that bear methoxy, hydroxyl, carboxylate, amido, keto, bromo, and fluoro groups can be assembled through this procedure. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19835369 |
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