| Title | A prospective multi-centre clinical trial to compare buprenorphine and butorphanol for postoperative analgesia in cats. | | Author(s) | Taylor PM, Kirby JJ, Robinson C, Watkins EA, Clarke DD, Ford MA, Church KE | | Institution | Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Nr Ely, Cambs CB6 2TY, UK. | | Source | J Feline Med Surg 2009 Oct 15. | | Abstract | One hundred and fifty-three cats undergoing surgery in seven veterinary practices in Great Britain were studied. They were randomly allocated to receive either 10-20mug/kg buprenorphine or 0.4mg/kg butorphanol with acepromazine before anaesthesia with propofol, Saffan or thiopentone and isoflurane or halothane. Routine monitoring was undertaken. Pain and sedation were assessed blind using a four point (0-3) simple descriptive scale (SDS) at 1, 2, 4, 8 and 24h. Pain and sedation data were compared using non-parametric statistical tests and continuous data using t tests or analysis of variance (ANOVA). Anaesthesia and surgery were uneventful, and cardiorespiratory data were within normal limits. After surgery, overall, more cats had pain score 0 after buprenorphine and more had pain score 3 after butorphanol (P=0.0465). At individual time points, more cats had lower pain scores after buprenorphine at 2 (P=0.040) and 24 (P=0.036)h. At 24h 83% after buprenorphine and 63% after butorphanol had pain score 0 (P<0.04). Buprenorphine provided better and longer lasting postoperative analgesia than butorphanol. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19836984 |
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