| Title | Influence of polymers ratio on insulin-loaded nanoparticles based on poly-epsilon-caprolactone and Eudragit RS for oral administration. | | Author(s) | Socha M, Sapin A, Damgé C, Maincent P | | Institution | Laboratory of Pharmaceutical Technology, School of Pharmacy, Nancy, France. | | Source | Drug Deliv 2009 Nov; 16(8):430-6. | | Abstract | Nanoparticles loaded with two different commercial insulins (Actrapid, Novorapid and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit RS) were characterized in vitro. The zeta potential was positive whenever Eudragit RS was part of the nanoparticles matrix. The encapsulation efficiency was ~ 96% except for Novorapid-loaded particles of poly-epsilon-caprolactone (only 35%). In vitro release studies revealed a burst release from nanoparticles, which may be of interest for oral delivery. Novorapid-loaded nanoparticles were orally administered to diabetic rats and allowed the glycemia to be decreased when compared with free nanoparticles. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19839787 |
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