High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry. Nanomedicine (London, England) [Nanomed] Journal article | | Title | High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry. | | Author(s) | Herrmann IK, Grass RN, Stark WJ | | Institution | Institute for Chemical & Bioengineering, Department of Chemistry & Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093, Zurich, Switzerland. wendelin.stark@chem.ethz.ch. | | Source | Nanomed 2009 Oct; 4(7):787-98. | | Abstract | The rapidly growing applications of nanomagnets in magnetic drug delivery and separation in clinical diagnostics require strong and reliable magnetic vehicles. Strength conveys rapid processing, high delivery/targeting yield and rapid results when used in clinics. Reliability enables recycling of nanomagnets, regulatory-conforming drug formulations and efficient use of (expensive) antibodies in diagnostics, combined with reduced leaching (reagent loss). The present work illustrates how metal-based nanomagnets provide a two-three-times stronger magnetic particle than conventional magnetite-based materials. Ligands, antibodies or drugs can be anchored to such carbon/metal core/shell nanomagnets over covalent, hydrolysis-resistant carbon-carbon bonds. This linker chemistry resists strong acids, sterilization and prolonged storage or aggressive treatment. As dispersions, functional nanomagnets rapidly scan liquids/tissue by Brownian diffusion, capture/deliver/react at a target and are efficiently recollected after use. Metal iron-based, carbon-coated nanomagnets consist of particularly well-accepted materials and now open stable nanomagnets to a broad range of fascinating separation problems in biomedical research. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19839814 |
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