Antibacterial, antifungal, and antiviral activities of some flavonoids. Microbiological research [Microbiol Res] Journal article | | Title | Antibacterial, antifungal, and antiviral activities of some flavonoids. | | Author(s) | Orhan DD, Ozçelik B, Ozgen S, Ergun F | | Institution | Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330 Ankara, Turkey. | | Source | Microbiol Res 2009 Oct 17. | | Abstract | Antibacterial and antifungal activities of six plant-derived flavonoids representing two different structural groups were evaluated against standard strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and their drug-resistant isolates, as well as fungi (Candida albicans, C. krusei) using the microdilution broth method. Herpes simplex virus Type-1 and Parainfluenza-3 virus were employed for antiviral assessment of the flavonoids using Madin-Darby bovine kidney and Vero cell lines. Ampicillin, gentamycin, ofloxacin, levofloxacin, fluconazole, ketoconazole, acyclovir, and oseltamivir were used as the control agents. All tested compounds (32-128mug/ml) showed strong antimicrobial and antifungal activities against isolated strains of P. aeruginosa, A. baumanni, S. aureus, and C. krusei. Rutin, 5,7-dimethoxyflavanone-4'-O-beta-d-glucopyranoside and 5,7,3'-trihydroxy-flavanone-4'-O-beta-d-glucopyranoside (0.2-0.05mug/ml) were active against PI-3, while 5,7-dimethoxyflavanone-4'-O-[2''-O-(5'''-O-trans-cinnamoyl)-beta-d-apiofuranosyl]-beta-d-glucopyranoside (0.16-0.2mug/ml) inhibited potently HSV-1. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19840899 |
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