| Title | Alternative Dosage of Zidovudine in Infants Exposed to Maternal Human Immunodeficiency Virus Infection. | | Author(s) | Frasca K, Fisher RG, McGuire E | | Institution | From the *Eastern Virginia Medical School, Norfolk VA; and daggerDepartment of Pediatrics, Division of Infectious Diseases, Eastern Virginia Medical School, Norfolk, VA. | | Source | Pediatr Infect Dis J 2009 Oct 16. | | Abstract | As part of the 076 protocol, ZDV was given to HIV-exposed neonates for the first 6 weeks of life. The dosage was 2 mg/kg every 6 hours. Frequent dosing can be a deterrent to regimen adherence. We report our experience, using 3 mg/kg every 8 hours in 155 eligible HIV-exposed neonates, none of whom became HIV infected. Maximum risk of transmission that could be missed by this cohort is approximately 2%, which is consonant with current transmission rates. ZDV at 3 mg/kg every 8 hours is noninferior to 2 mg/kg every 6 hours and easier to administer. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19841608 |
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