Growth factors, inflammatory cytokines and postnatal bone strength in preterm infants. Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] Journal article | | Title | Growth factors, inflammatory cytokines and postnatal bone strength in preterm infants. | | Author(s) | Eliakim A, Nemet D, Ahmad I, Zaldivar F, Koppel R, Grochow D, Waffarn F, Cooper DM | | Institution | Child Health and Sports Center, Pediatric Department, Meir Medical Center, Kfar Saba, Israel. eliakim.alon@clalit.org.il | | Source | J Pediatr Endocrinol Metab 2009 Aug; 22(8):733-40. | | Abstract | AIM: To assess the relationships between growth factors, inflammatory cytokines and postnatal bone development in preterm infants.
METHODS: Fifty premature infants (24-32 weeks gestational age, mean birth weight: 1,024 +/- 50 g) participated in the study. Bone strength was determined weekly by quantitative ultrasound measurements of bone speed of sound (SOS). Blood serum measurements of growth factors included circulating IGF-I and GH binding protein. Measurements of circulating cytokines included the pro-inflammatory mediator interleukin (IL)-6, and the anti-inflammatory mediator IL-1 receptor antagonist. Samples were collected when the preterm infants were stabilized and prior to discharge.
RESULTS: Despite a significant increase in body weight (from 1,024 +/- 50 to 2,420 +/- 59 g, p < 0.001) and body length (from 35.4 +/- 0.6 to 44.6 +/- 0.4 cm, p < 0.001) there was a significant decrease in bone SOS during the follow-up period. There was a significant increase in growth factors and a decrease in inflammatory cytokines during the follow-up. Participants were divided into preterm infants who increased bone SOS (bone gainers, n = 16, from 2,867 +/- 38 to 2,910 +/- 41 m/sec), or decreased bone SOS (bone losers, n = 34, from 2,967 +/- 33 to 2,818 +/- 28 m/sec) during follow-up. Baseline bone SOS was significantly lower in the bone gainers. Baseline circulating growth factors were higher and inflammatory cytokines lower in the bone gainers; however, only the difference in IL-6 reached statistical significance (6.4 +/- 1.6 versus 10.5 +/- 1.2 pg/ml, in bone gainers and losers, respectively; p < 0.05).
CONCLUSIONS: Preterm infants with lower bone SOS at birth tend to 'catch-up' during early postnatal weeks. Increases in bone strength in preterm infants were associated with reduced inflammatory state as suggested by lower levels of circulating IL-6. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19845124 |
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