| Title | Prognostic Value of Serum Tumor Antigen CA19-9 After Curative Resection of Colorectal Cancer. | | Author(s) | Park IJ, Choi GS, Jun SH | | Institution | Department of Surgery, School of Medicine, Kyungpook National University 50 Samduk-dong 2ga Jung-gu, Daegu, Korea. kyuschoi@mail.knu.ac.kr. | | Source | Anticancer Res 2009 Oct; 29(10):4303-8. | | Abstract | BACKGROUND: CA19-9 was evaluated as a prognostic marker for colorectal cancer and whether it could be helpful in addition to surveillance using CEA was also tested.
MATERIALS AND METHODS: Serum CA19-9 levels were measured preoperatively in 1109 patients and monitored at 3-month intervals for the first 2 years postoperatively, and at 6-month intervals thereafter in 700 patients.
RESULTS: Preoperative high CA19-9 was independent prognostic factor for recurrence. Among patients with recurrence, 21.4% had a high postoperative CA19-9. High postoperative CA 19-9 levels were more likely in patients with high preoperative levels. Postoperative CA19-9 increased more in patients with a peritoneal recurrence than in those with liver metastasis (p=0.002). Among patients with recurrence, CA19-9 increased in 7.8% of the patients with a normal follow-up CEA.
CONCLUSION: Postoperative CA19-9 was more frequently elevated when peritoneal recurrence occurred. Data on CA19-9 levels provided 7.8% of additional information in predicting recurrence in this study. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19846991 |
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