| Title | Selection for increased nitric oxide production does not increase resistance to Marek's disease in a primary broiler breeder line. | | Author(s) | Buscaglia C, O'Connell PH, Jarosinski KW, Pevzner I, Schat KA | | Institution | Cátedra de Zootecnia Especial III (Aves y Piliferos), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, CC 296 (B190AVW) La Plata, Argentina. | | Source | Avian Dis 2009 Sep; 53(3):336-40. | | Abstract | Two primary broiler breeder lines, A and B, were examined for their potential to produce nitric oxide (NO) after stimulating splenocytes from 20-day-old embryos with lipopolysaccharide and interferon-gamma. Significant differences were found between lines A and B. Overall, line A had a higher response than line B, but line A also had a large degree of variation between individual sire families. Selection for high and low responders within line A resulted in the segregation of high- and low-responder sire families. Offspring from sire families selected for high and low NO responses and from a nonselected control group from line A were challenged with RB-1B Marek's disease (MD) virus to determine whether these differences could be used to select for improved resistance to MD. Virus isolation rates at 6 and 10 days postinfection were not significantly different, but unexpectedly, the MD incidence in the high-responder group was significantly higher than in the other two groups. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19848069 |
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