| Title | Drug release from lipid liquid crystalline phases: relation with phase behavior. | | Author(s) | Costa-Balogh FO, Sparr E, Sousa JJ, Pais AC | | Institution | Centro de Estudos Farmacêuticos, Laboratório de Galénica e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Coimbra, Portugal. | | Source | Drug Dev Ind Pharm 2009 Oct 22. | | Abstract | Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems.
Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases.
Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution.
Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19848561 |
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