| Title | Post-dauer Life Span of Caenorhabditis Elegans Dauer Larvae Can be Modified by X-irradiation. | | Author(s) | Onodera A, Yanase S, Ishii T, Yasuda K, Miyazawa M, Hartman PS, Ishii N | | Institution | Department of Molecular Life Science, Tokai University School of Medicine. | | Source | J Radiat Res (Tokyo) 2009 Oct 23. | | Abstract | The time spent as a dauer larva does not affect adult life span in Caenorhabditis elegans, as if aging is suspended in this quiescent developmental stage. We now report that modest doses X-irradiation of dauer larvae increased their post-dauer longevity. Post-irradiation incubation of young dauer larvae did not modify this beneficial effect of radiation. Conversely, holding dauer larvae prior to irradiation rendered them refractory to this X-radiation-induced response. We present a model to explain these results. These experiments demonstrate that dauer larvae provide an excellent opportunity to study mechanisms by which X irradiation can extend life span. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19851044 |
|
