Occluding the round window causes no change in threshold, but an increase in hearing loss following noise exposure. Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] Journal article

Title	Occluding the round window causes no change in threshold, but an increase in hearing loss following noise exposure.
Author(s)	Perez R, Adelman C, Sichel JY, Sohmer H
Institution	Department of Otolaryngology and Head & Neck Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.
Source	J Basic Clin Physiol Pharmacol 2009; 20(3):197-205.
Abstract	AIM: To assess the effects of occluding the round window on the degree of hearing loss following exposure to broad band noise. DESIGN: Following opening of the middle ear bulla in both ears of ten sand rats, auditory nerve-brainstem evoked response (ABR) thresholds were determined in each ear separately using an insert earphone. The round window of one ear was then occluded with super-glue. The opposite ear was sham-operated. ABR thresholds were again assessed immediately. The animals were then exposed to 113 dB SPL broad band noise for 12 hours. 24 hours after the round window was occluded, which was 8-10 hours after the end of the noise exposure, ABR thresholds were again determined in each ear. In four control animals, the round window was blocked, but they were not exposed to noise. RESULTS: Following the noise exposure, the mean ABR threshold elevation in the round window blocked ears (54.5 +/- 5.5 dB) was significantly (p < 0.004) greater than that in the sham-operated ear (40.5 +/- 8.6 dB). In the four control ears, there was no change in ABR threshold 24 hours after the round window was occluded. CONCLUSION: Occluding the round window was not accompanied by a threshold elevation, but following noise exposure, the noise induced hearing loss was increased, probably by reducing the efficacy of an inherent protective mechanical mechanism.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	19852307

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