| Title | Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands. | | Author(s) | Aberg K, Dai F, Viali S, Tuitele J, Sun G, Indugula SR, Deka R, Weeks DE, McGarvey ST | | Source | BMC Med Genet 2009 Oct 23; 10(1):107. | | Abstract | ABSTRACT:
BACKGROUND: High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental and behavioral factors such as smoking, alcohol consumption, physical activity and material lifestyle.
RESULTS: We found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively.
CONCLUSION: We have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19852796 |
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