Bharti S, Wahane VD, Kumar VL
Protective effect of Calotropis procera latex extracts on experimentally induced gastric ulcers in rat. [JOURNAL ARTICLE]
J Ethnopharmacol 2009 Oct 20.
AIM OF THE STUDY: Calotropis procera is a wild growing plant with multifarious medicinal properties. The present study was carried out to evaluate the effect of dried latex (DL) of C. procera and its methanol extract (MeDL) against gastric ulcers induced in rats.
MATERIALS AND METHODS: Aqueous suspension of DL (20 and 100mg/kg) and MeDL (10 and 50mg/kg) were given orally to 36 hr fasted rats and ulcers were induced by ethanol, pyloric ligation and aspirin. Parameters like ulcer score and levels of oxidative stress markers were measured in all the models. The effect on gastric hemorrhage and tissue histology was studied in ethanol model and on acidity, pH and volume of gastric secretion was evaluated in pyloric ligation model. The protective effect of DL and MeDL was compared with that of standard anti-ulcer drug famotidine (20mg/kg).
RESULTS: DL and MeDL produced 85 to 95% inhibition of gastric mucosal damage in ethanol model and 70 to 80% inhibition in aspirin model. The protective effect of these extracts was associated with marked reduction in gastric hemorrhage, maintenance of tissue integrity and normalization of levels of oxidative stress markers like glutathione, thiobarbituric acid reactive substances and superoxide dismutase. Like famotidine, DL and MeDL decreased the gastric acidity from 376.17+/-21.47 mEq/L to 163.88+/-6.86 and 201.48+/-8.86 mEq/L respectively in pyloric ligation model. These extracts increased the gastric pH without affording any protection to gastric mucosa in this model.
CONCLUSION: The latex of C. procera has the therapeutic potential to relieve gastric hyperacidity and to prevent gastric ulceration induced by necrotizing agents.
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