Pharmacokinetics of oral gabapentin in greyhound dogs. Veterinary journal (London, England : 1997) [Vet J] Journal article | | Title | Pharmacokinetics of oral gabapentin in greyhound dogs. | | Author(s) | Kukanich B, Cohen RL | | Institution | Kansas State University, College of Veterinary Medicine, Department of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506, USA. | | Source | Vet J 2009 Oct 22. | | Abstract | The purpose of this study was to assess the pharmacokinetics of gabapentin in healthy greyhound dogs after single oral doses targeted at 10 and 20mg/kg PO. Six healthy greyhounds were enrolled (3 males, 3 females). Blood was obtained at predetermined times for the measurement of gabapentin plasma concentrations by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were determined with computer software. The actual mean (and range) doses administered were 10.2 (9.1-12.0) mg/kg and 20.5 (18.2-24) mg/kg for the 10mg/kg and 20mg/kg targeted dose groups. The mean C(MAX) for the 10 and 20mg/kg groups were 8.54 and 13.22mug/mL at 1.3 and 1.5h, and the terminal half-lives were 3.3 and 3.4h, respectively. The relative bioavailability of the 10mg/kg group was 1.13 compared to the 20mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs, indicating that frequent dosing is needed to maintain minimum targeted plasma concentrations. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19854080 |
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