| Title | Epigenetic therapies for chemoresensitization of epithelial ovarian cancer. | | Author(s) | Matei DE, Nephew KP | | Institution | Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Obstetrics and Gynecology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA. | | Source | Gynecol Oncol 2009 Oct 23. | | Abstract | Epigenetic drugs have been shown to enhance gene expression and drug sensitivity in ovarian cancer cell lines and animal models. Based on promising preclinical studies, DNA methylation inhibitors in combination with existing chemotherapeutic agents have the potential for overcoming acquired drug resistance, laying the foundation for this specific class of epigenetic drug in ovarian cancer clinical trials. The recent completion of phase I trials of decitabine has yielded important information on dosing schedules and biological endpoints for evaluating patient responses. In addition, epigenetic drug effects on pharmacodyamic targets are beginning to emerge, and predictive epigenetic biomarkers and next generation epigenome therapeutics are being developed for application in clinical settings for ovarian cancer patients. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19854495 |
|
