| Title | Sirolimus Attenuates Reduced-Size Liver Ischemia-Reperfusion Injury But Impairs Liver Regeneration in Rats. | | Author(s) | Liu YX, Jin LM, Zhou L, Xie HY, Jiang GP, Chen H, Zheng SS | | Institution | Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, 310003, Hangzhou, Zhejiang Province, People's Republic of China. | | Source | Dig Dis Sci 2009 Oct 24. | | Abstract | BACKGROUND: Evidence has suggested that immunosuppressive drugs impact ischemia-reperfusion injury.
AIMS: The purpose of the present study was to evaluate the effect of sirolimus on hepatic injury and regeneration in a rat reduced-size liver ischemia-reperfusion model.
METHODS: Using a newly developed rat reduced-size liver ischemia-reperfusion injury model, the effects of sirolimus were evaluated by assessing liver cell apoptosis and aspartate aminotransferase, myeloperoxidase, and malondialdehyde levels. In addition, liver regeneration after sirolimus treatment was evaluated by measuring liver weight resumption and by the histological examination of bromodeoxyuridine and proliferating cell nuclear antigen expression.
RESULTS: Sirolimus significantly decreased liver cell apoptosis as well as tissue myeloperoxidase and malondialdehyde levels, but impaired postischemic liver regeneration. Ischemia-reperfusion-induced elevation of aspartate aminotransferase serum levels was significantly decreased by sirolimus.
CONCLUSIONS: Despite an impairment of postischemic liver proliferation, sirolimus demonstrated beneficial amelioration of ischemia-reperfusion-induced liver injury in a reduced-size liver model in rats. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19856103 |
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