| Title | Ifosfamide encephalopathy and use of methylene blue. A case report of different sequential neurotoxicity. | | Author(s) | Giovanis P, Garna A, Marcante M, Nardi K, Giusto M | | Institution | Operative Unit of Medical Oncology, City Hospital of Belluno, Belluno, Italy. petros.giovanis@ulss.belluno.it | | Source | Tumori 2009 Jul-Aug; 95(4):545-6. | | Abstract | Neurotoxicity is a clinically relevant adverse event observed with the use of ifosfamide. It is usually mild, occasionally severe and seldom fatal. Ifosfamide-induced encephalopathy requires interruption of chemotherapy, intravenous hydration and administration of methylene blue. Less is known about the efficacy of methylene blue in avoiding a second episode of ifosfamide-induced encephalopathy while maintaining chemotherapy with ifosfamide. We report a case of a different clinical manifestation of ifosfamide-induced encephalopathy after continued ifosfamide use and despite methylene blue in a patient with retroperitoneal sarcoma. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19856674 |
|
