Wang W, Xue L, Liu H, Wang P, Xu P, Cai Y
Aberrant Changes of Wnt2/beta-Catenin Signaling Pathway Induced by Sodium Nitroprusside in Human Esophageal Squamous Cell Carcinoma Cell Lines. [JOURNAL ARTICLE]
Cancer Invest 2009 Oct 26.
ABSTRACT Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. However, little is known about the role of Wnt2/beta-catenin pathway in esophageal squamous cell carcinoma (ESCC). Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.
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