| Title | Aberrant Changes of Wnt2/beta-Catenin Signaling Pathway Induced by Sodium Nitroprusside in Human Esophageal Squamous Cell Carcinoma Cell Lines. | | Author(s) | Wang W, Xue L, Liu H, Wang P, Xu P, Cai Y | | Institution | Laboratory for Cell Biology, The First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan 450052, China 1. | | Source | Cancer Invest 2009 Oct 26. | | Abstract | ABSTRACT Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. However, little is known about the role of Wnt2/beta-catenin pathway in esophageal squamous cell carcinoma (ESCC). Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19857041 |
|
