| Title | Long QT syndrome and torsades de pointes induced by acute sulpiride poisoning. | | Author(s) | Chang JH, Weng TI, Fang CC | | Institution | Institute of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. | | Source | Am J Emerg Med 2009 Oct; 27(8):1016.e1-3. | | Abstract | Sulpiride, a selective dopamine D2 antagonist and a substituted benzamide derivative, is considered a safe antipsychotic and antidepressant agent with few adverse effects on the cardiovascular system. Sulpiride-induced torsades de pointes is rare. We report a case of long QT syndrome and torsades de pointes induced by ingestion of 1.5 g of sulpiride. Ventricular arrhythmia was initially treated with amiodarone, without success. Eventually, lidocaine and magnesium sulfate successfully terminated the ventricular arrhythmia. The patient was discharged uneventfully after 3 days of hospitalization. This case illustrates the fact that acute sulpiride poisoning may lead to life-threatening ventricular arrhythmia. Early recognition followed by effective therapy is crucial. Intensive cardiac monitoring is recommended for sulpiride poisoning. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19857426 |
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