| Title | Fulminant Hepatic Failure Induced by Venlafaxine and Trazodone Therapy: A Case Report. | | Author(s) | Detry O, Delwaide J, De Roover A, Hans MF, Delbouille MH, Monard J, Honoré P | | Institution | Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, Belgium. | | Source | Transplant Proc 2009 Oct; 41(8):3435-3436. | | Abstract | Although acute hepatitis may be a side effect of many medications, most cases are reversible after treatment interruption, and fulminant hepatic failure (FHF) is rare. Venlafaxine and trazodone are 2 popular antidepressant agents. Alteration of liver enzyme levels has been reported as a side effect of these drugs at normal doses. Herein we have reported the case of a 48-year-old woman without any previous history of liver disease, who developed fulminant liver failure after 4 months of venlafaxine and trazodone therapy. She required liver transplantation, a procedure that was successful with full patient recovery. The first 5 years of follow-up were uneventful. This case documented that venlafaxine and trazodone at normal doses can produce severe liver toxicity. Liver tests should be monitored regularly in patients who receive this therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19857765 |
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