Authier S, Tanguay JF, Geoffroy P, Gauvin D, Bichot S, Ybarra N, Otis C, Troncy E
Cardiovascular Effects of Oxytocin Infusion in a Porcine Model of Myocardial Infarct. [JOURNAL ARTICLE]
J Cardiovasc Pharmacol 2009 Oct 23.
The effects of OT on cardiovascular endpoints were assessed in a myocardial infarct (MI) model. OT (10 ng.kg.hr) or saline infusion was initiated at reperfusion (D0) or 8 days (D8) after MI. Our hypothesis was that OT administration to individuals with a low pre-treatment OT levels (PTOT) may be beneficial, whereas individuals with an elevated PTOT would be prone to adverse effects. Starting OT on D0 reduced left ventricular fraction shortening evaluated 8 days post-MI, and had no effect on infarct size. OT initiated on D8 in animals with high PTOT decreased ejection fraction (EF) and increased left ventricular end systolic diameter (LVESD) at 28 days post-MI, but had no significant effects on EF and LVESD in low PTOT animals. OT infusion reduced OT receptor (OTR) protein expression in high PTOT animals but not in low PTOT animals. Amongst placebo-treated individuals, low PTOT presented a trend towards reduced EF and larger infarct size compared with high PTOT. MI areas of fibrosis presented lower Annexin-V expression compared with MI with cardiomyocyte predominance. Pre-treatment endogenous OT levels and timing of OT administration post-MI appear to impact outcome in this porcine model and further investigations are warranted to define potential role of OT in cardiac regenerative therapy.
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