George I, Xydas S, Klotz S, Hay I, Ng C, Chang J, Xu K, Li Z, Protter AA, Wu EX, Oz MC, Wang J
Long-Term Effects of B-Type Natriuretic Peptide Infusion Following Acute Myocardial Infarction in a Rat Model. [JOURNAL ARTICLE]
J Cardiovasc Pharmacol 2009 Oct 23.
INTRODUCTION:: The effects of exogenous B-type natriuretic peptide (BNP) on post-myocardial infarction (MI) are not known. We tested the hypothesis that in-vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI.
METHODS:: MI was induced by coronary ligation in rats and confirmed by echocardiography. 19 rats were randomized to 1 of 3 groups: Sham (n=7); MI + saline (n=5); MI + BNP (400 ng/kg/min) (n=7). Infusions were delivered for 7 days via venous catheters tunneled to an infusion pump. Rats were followed for 8 wks. Echocardiography, hemodynamics, histology and in vivo and ex vivo pressure-volume relationships were examined.
RESULTS:: LV systolic pressure, LV dP/dtmax, and infarct size improved with BNP treatment vs. control MI group (132+/-4 vs. 110+/-2 mmHg, 8097+/-317 vs. 5816+/-378 mmHg/s, 19.3+/-1.6 vs. 23.3+/-1.9%, respectively, all p<0.05). Ex-vivo end-diastolic pressure-volume relationship demonstrated reduced diastolic dysfunction after BNP therapy (p<0.05 vs. control MI). Serum BNP levels confirmed delivery of BNP.
CONCLUSION:: We demonstrate beneficial effects on LV function and decreased LV remodeling with BNP infusion in an experimental model of acute MI.
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