| Title | Long-Term Effects of B-Type Natriuretic Peptide Infusion Following Acute Myocardial Infarction in a Rat Model. | | Author(s) | George I, Xydas S, Klotz S, Hay I, Ng C, Chang J, Xu K, Li Z, Protter AA, Wu EX, Oz MC, Wang J | | Institution | 1Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY 2Department of Medicine, Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 3Scios Inc., Fremont, CA 4Faculty of Engineering, The University of Hong Kong, Hong Kong 5Institute of Molecular and Experimental Therapeutics, East China Normal University, Shanghai, P.R. of China. | | Source | J Cardiovasc Pharmacol 2009 Oct 23. | | Abstract | INTRODUCTION:: The effects of exogenous B-type natriuretic peptide (BNP) on post-myocardial infarction (MI) are not known. We tested the hypothesis that in-vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI.
METHODS:: MI was induced by coronary ligation in rats and confirmed by echocardiography. 19 rats were randomized to 1 of 3 groups: Sham (n=7); MI + saline (n=5); MI + BNP (400 ng/kg/min) (n=7). Infusions were delivered for 7 days via venous catheters tunneled to an infusion pump. Rats were followed for 8 wks. Echocardiography, hemodynamics, histology and in vivo and ex vivo pressure-volume relationships were examined.
RESULTS:: LV systolic pressure, LV dP/dtmax, and infarct size improved with BNP treatment vs. control MI group (132+/-4 vs. 110+/-2 mmHg, 8097+/-317 vs. 5816+/-378 mmHg/s, 19.3+/-1.6 vs. 23.3+/-1.9%, respectively, all p<0.05). Ex-vivo end-diastolic pressure-volume relationship demonstrated reduced diastolic dysfunction after BNP therapy (p<0.05 vs. control MI). Serum BNP levels confirmed delivery of BNP.
CONCLUSION:: We demonstrate beneficial effects on LV function and decreased LV remodeling with BNP infusion in an experimental model of acute MI. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19858735 |
|
