Puthanakit T, Chokephaibulkit K, Suntarattiwong P, Gorowara M, Vanprapar N, Leawsrisuk P, Suwanlerk T, Boonrak P, Ruxrungtham K
THERAPEUTIC DRUG MONITORING OF LOPINAVIR IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN RECEIVING ADULT TABLETS: THERAPEUTIC DRUG MONITORING OF LOPINAVIR TABLETS GIVEN TO CHILDREN. [JOURNAL ARTICLE]
Pediatr Infect Dis J 2009 Oct 24.
Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (Ctrough) was 6.7 (5.0-9.9) mg/L. All the children had Ctrough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.
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