| Title | The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent. | | Author(s) | Parra A, Vinader-Caerols C, Ferrer-Añó A, Urquiza A, Monleón S | | Institution | Unviersidad de Valencia. | | Source | Psicothema 2009 Nov; 21(4):528-30. | | Abstract | The purpose of the present work was to study the dose-effect relationship of the antidepressant amitriptyline on inhibitory avoidance in male and female mice. Subjects received physiological saline or 2.5, 5, 10 or 20 mg/kg of amitriptyline hydrochloride 30 min before the training phase, and were subjected to the test phase 24 h later. Results showed a clear impairing effect of amitriptyline on inhibitory avoidance in both male and female mice, and that the effect is dose-dependent. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19861093 |
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