Effects of Naturally Occurring Polymethyoxyflavonoids on Cell Growth, P-Glycoprotein Function, Cell Cycle, and Apoptosis of Daunorubicin-Resistant T Lymphoblastoid Leukemia Cells. Cancer investigation [Cancer Invest] Journal article | | Title | Effects of Naturally Occurring Polymethyoxyflavonoids on Cell Growth, P-Glycoprotein Function, Cell Cycle, and Apoptosis of Daunorubicin-Resistant T Lymphoblastoid Leukemia Cells. | | Author(s) | Ishii K, Tanaka S, Kagami K, Henmi K, Toyoda H, Kaise T, Hirano T | | Institution | Departments of Clinical Pharmacology1 and Clinical Molecular Genetics,2 School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences,3 Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan. | | Source | Cancer Invest 2009 Oct 28. | | Abstract | ABSTRACT Effects of polymethoxyflavonoids tangeretin and nobiletin and the related polyphenolic compounds baicalein, wogonin, quercetin, and epigallocatechin gallate on the cell growth, P-glycoprotein function, apoptosis, and cell cycle of human T lymphoblastoid leukemia MOLT-4 and its daunorubicin-resistant cells were investigated. The IC50 values of these compounds on the cell growth were 7.1-32.2 mumol/L, and the inhibitory effects were observed to be almost equal to the parent MOLT-4 and the daunorubicin-resistant cells. Tangeretin and nobiletin showed the strongest effects with the IC50 values of 7.1-14.0 mumol/L. These polymethoxyflavonoids inhibited the P-glycoprotein function and significantly influenced the cell cycle (p<.05), whereas they did not induce apoptosis. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19863351 |
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