Martinez-Aguayo A, Hernández MI, Capurro T, Peña V, Avila A, Salazar T, Asenjo S, Iñiguez G, Mericq V
Leuprolide acetate gonadotropin response patterns during female puberty. [JOURNAL ARTICLE]
Clin Endocrinol (Oxf) 2009 Oct 26.
SUMMARY
Objective: To assess normative data and the usefulness of spontaneous and LHRH analogue-stimulated serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels measured by IRMA in the evaluation of normal puberty.
Design: Prospective. Healthy girls in Tanner I and Tanner II from the local community were invited to participate (N=47).
Methods: A leuprolide acetate test (500 mcg/m(2); sc) was performed. LH and FSH levels were determined using IRMA. Tanner II girls were assessed every six months until Tanner V. Girls who progressed from Tanner II to Tanner III in the next six months were called Tanner II-2; otherwise, they were called Tanner II-1.
Results: The prepubertal upper limit [CI 95%] was 0.49 IU/L for basal LH and 5.1 IU/L for stimulated LH. Taking into account these LH cut-off limits, 72.2% and 66.7% of Tanner II-1 and 41.6% and 41.7% of Tanner II-2 subjects presented overlapping values for basal and stimulated LH, respectively, as compared with the Tanner I group. The cut-offs for basal and stimulated LH to predict progression from Tanner II to Tanner III in the next six months were a basal LH level >/= 0.49 IU/L (Sensitivity=0.58; 1 - Specificity=0.33) and a post-stimulated LH level >/= 4.75 IU/L (Sensitivity=0.67; 1 - Specificity=0.44).
Conclusion: According to an IRMA, the basal and leuprolide acetate gonadotropin response patterns during the beginning stages of puberty overlapped between Tanner I and Tanner II, and the cut-offs of basal and stimulated LH levels to predict progress from Tanner II to Tanner III had low sensitivities for the following six months.
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