Treatment of hyper-IgG4 disease with sequential corticosteroids and tamoxifen - case report and review of the literature. Clinical nephrology [Clin Nephrol] Journal article | | Title | Treatment of hyper-IgG4 disease with sequential corticosteroids and tamoxifen - case report and review of the literature. | | Author(s) | Chacko S, Taskapan H, Roscoe J, Stein J, Woods E, Denton T, Ting R, Tam P, Oreopoulos DG, Rodriguez-Justo M, Sikaneta T, 1Department of Family Medicine, University of Toronto, Toronto, 2Nephrology Associates, Scarborough, Ontario, 3Departments of Nephrology and Medicine, Scarborough General Hospital, 4Departments of Rheumatology and Medicine, 5Department of Urology, 6Diagnostic Imaging, Humber River Regional Hospital, 7Departments of Nephrology and Medicine, University Health Network, Toronto, Ontario, Canada, and 8Department of Histopathology, Royal Free and University College Medical School, University College H | | Source | Clin Nephrol 2009 Nov; 72(5):414-3. | | Abstract | We report a patient with multifocal fibrosclerosis presenting as sialadenitis, hepatic fibrosis, and retroperitoneal fibrosis with renal failure. His medical management consisted of prednisone (4 months at 40 mg daily, then tapered down to 5 mg daily for another 14 months) and 18 months of tamoxifen. He responded clinically and radiographically to this regimen, and remains in clinical remission 10 months after discontinuing medical therapy. Subsequent histologic examination of submandibular gland tissue revealed strong staining for IgG4-positive plasma cells. To our knowledge, this is the first case of confirmed multifocal hyper-IgG4 disease to be successfully treated with sequential corticosteroids and tamoxifen. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19863888 |
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