| Title | Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines. | | Author(s) | Saliba R, Paasch L, El Solh A | | Institution | The Veterans Affairs Western New York Healthcare System, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York 14215-1199, USA. | | Source | Immunopharmacol Immunotoxicol 2009; 31(4):583-8. | | Abstract | The purpose of this study is to examine the in vitro modulatory effect of tigecycline on staphylococcal superantigen-induced T-cell activation and cytokines and chemokines production by human peripheral blood mononuclear cells (PBMC). Isolated human PBMC from ten healthy volunteers were stimulated by staphylococcal enterotoxin B (SEB) and Staphylococcal toxic shock syndrome toxin-1 (TSST-1) superantigens with varying concentrations of tigecycline. Cytokines IL-1 beta, IL-6, TNF-alpha, and chemokines MIP-1 alpha and MIP-1 beta concentrations were measured along with T cell proliferation. Results demonstrated that tigecycline alters cytokine production and reduces T-cell proliferation in vitro suggesting an immunomodulatory activity independent of its antimicrobial effect. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19874226 |
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