| Title | Potential biomarkers of smoked fentanyl utilizing pyrolysis gas chromatography-mass spectrometry. | | Author(s) | Nishikawa RK, Bell SC, Kraner JC, Callery PS | | Institution | Eugene C Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA. rnishika@mix.wvu.edu | | Source | J Anal Toxicol 2009 Oct; 33(8):418-22. | | Abstract | Fentanyl is a potent opioid analgesic that is increasingly becoming a choice drug of abuse. Fentanyl transdermal patches (FTPs) are easily obtained and consumed by smoking the reservoir gel and/or the whole patch. This allows for an increased bioavailability when inhaled. A method using analytical pyrolysis was developed to identify possible biomarkers associated with smoked fentanyl and FTPs. Pyrolysis was carried out under anaerobic and aerobic conditions using helium and air coupled to a gas chromatograph-mass spectrometer. The presence of a trap enhanced recovery and afforded a positive identification of pyrolytic products. Anaerobic and aerobic pyrolysis of fentanyl and FTPs consistently yielded propionanilide as the major pyrolytic product along with pyridine and previously reported metabolites (norfentanyl and despropionyl fentanyl). Analysis of fentanyl resulted in chlorine-containing compounds, presumably formed from the HCl salt of fentanyl. Analysis of FTPs showed significant polymeric and hydrocarbon compounds and products likely derived from the gel matrix. Fentanyl in the FTPs was in the citrate salt form; therefore, the chlorine-containing pyrolytic products obtained with the neat drug were not observed. Based on this application, it may be possible to identify what salt form of the drug was smoked based on pyrolytic products and to target distinguishing metabolic products for future research. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19874647 |
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