| Title | Asymmetric Conjugate Reductions of Coumarins. A New Route to Tolterodine and Related Coumarin Derivatives. | | Author(s) | Gallagher BD, Taft BR, Lipshutz BH | | Institution | Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106. | | Source | Org Lett 2009 Oct 30. | | Abstract | The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichiometric DEMS (diethoxymethylsilane) in toluene at room temperature leads to asymmetric reductions of 4-substituted coumarins. Several targets or their known precursors can be prepared in high yields and ee's, including the muscarine receptor antagonist (R)-tolterodine. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19877705 |
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