| Title | Development and validation of a disease-specific quality of life questionnaire for gastro-oesophageal reflux disease (GORD): the GORD-QOL questionnaire. | | Author(s) | Chan Y, Ching JY, Cheung CM, Tsoi KK, Polder-Verkiel S, Pang SH, Quan WL, Kee KM, Chan FK, Sung JJ, Wu JC | | Institution | Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. | | Source | Aliment Pharmacol Ther 2009 Oct 31. | | Abstract | Abstract
Background: A simple and meaningful health-related quality of life (HRQoL) questionnaire for gastro-oesophageal reflux disease (GORD) patients is lacking.
Aim: To develop and validate a disease-specific HRQoL instrument (GORD-QOL) for GORD patients.
Methods: An 18-item questionnaire was generated to measure the impact of GORD on sleep, exercise, diet, need of medication, sex life, work, social activity and psychological well-being. GORD patients were invited to complete the GORD-QOL, a visual analogue scale (VAS) and a validated Chinese generic QoL (SF-36) questionnaire before and after esomeprazole treatment. Factor analysis was performed for item selection and psychometric properties were measured. An English version was developed by a forward-backward translation process.
Results: A final 16-item GORD-QOL questionnaire was developed. The items were grouped into 4 subscales (Daily activity, Treatment effect, Diet, and Psychological well-being) after factor analysis. GORD-QOL had good item-internal consistency (Cronbach's alpha: 0.64-0.88), high test-retest reliability (intraclass correlation coefficient: 0.73-0.94, p<0.001). Its subscale scores were correlated with SF-36 and VAS, which demonstrated high construct validity (p<0.001). Discriminant validity was verified by correlating GORD-QOL scores with symptom severity (p<0.001). Responsiveness after esomeprazole treatment was significant (paired-t-test p<0.001). An English version of GORD-QOL was developed.
Conclusion: GORD-QOL is a valid and reliable instrument. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19878152 |
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