| Title | 4-phenyl butyric acid does not generally reduce glucose level in diabetic rodent models. | | Author(s) | Xu TY, Chen RH, Wang P, Zhang RY, Ke SF, Miao CY | | Institution | Department of Pharmacology, Second Military Medical University, Shanghai 200433, China. | | Source | Clin Exp Pharmacol Physiol 2009 Oct 29. | | Abstract | Summary 1. Endoplasmic reticulum (ER) stress plays a role in the pathogenesis of diabetes. The present study was to investigate the effect of 4-phenyl butyric acid (PBA), a novel chemical chaperone reducing ER stress, on the serum glucose level in different types of normal and diabetic rodents. 2. PBA significantly reduced the serum glucose level in obese type 2 diabetic ob/ob mice. Normoglycemia was obtained in ob/ob mice after 4 days of PBA treatment and maintained for up to 14 days of treatment period. 3. PBA had no glucose-lowering effect in alloxan-induced type 1 diabetic mice, hydrocortisone-induced type 2 diabetic mice, and non-obese type 2 diabetic Goto-Kakizaki rats. Also, it had no beneficial effect on insulin resistance in hydrocortisone treated mice. 4. PBA did not affect the normal serum glucose level in C57BL/6J mice, Kunming mice and Wistar-Kyoto rats. 5. In conclusion, PBA does not generally reduce glucose level in diabetic rodent models although it can normalize glucose level in ob/ob diabetic mice, indicating that restoring ER function for diabetes therapy is applicable only to limited types of diabetes in which ER stress is involved in high glucose level. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19878212 |
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