| Title | Mst Out and HCC In. | | Author(s) | Zhao B, Lei Q, Guan KL | | Institution | Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA. | | Source | Cancer Cell 2009 Nov 6; 16(5):363-4. | | Abstract | Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19878866 |
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