| Title | JAK2 Gets Histone H3 Rolling. | | Author(s) | Sattler M, Griffin JD | | Institution | Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. | | Source | Cancer Cell 2009 Nov 6; 16(5):365-6. | | Abstract | Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19878867 |
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