Fearon ER
PARsing the Phrase "All in for Axin"- Wnt Pathway Targets in Cancer. [Journal Article]
Cancer Cell 2009 Nov 6; 16(5):366-8.
Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.
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