| Title | PARsing the Phrase "All in for Axin"- Wnt Pathway Targets in Cancer. | | Author(s) | Fearon ER | | Institution | Division of Molecular Medicine & Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and The Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-22200, USA. | | Source | Cancer Cell 2009 Nov 6; 16(5):366-8. | | Abstract | Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19878868 |
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