Lucas-Filho MD, Silva GC, Cortes SF, Mares-Guia TR, Perpétua Ferraz V, Serra CP, Braga FC
ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. [JOURNAL ARTICLE]
Phytomedicine 2009 Oct 28.
Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC(50)=4.53+/-0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and beta-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC(50)=5.86+/-0.33) and its activity did not differ from captopril, when both compounds were assayed at 10muM concentration.
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