| Title | Synthesis of fluorescent C(24)-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin. | | Author(s) | Novotný J, Pospěchová K, Hrabálek A, Cáp R, Vávrová K | | Institution | Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic. | | Source | Bioorg Med Chem Lett 2009 Oct 15. | | Abstract | Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19879139 |
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