| Title | Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice. | | Author(s) | Gong YX, Zhang WP, Shou WT, Zhong K, Chen Z | | Institution | Department of Pharmacology, Yunyang medical college, Shiyan, China; Institute of Neuroscience, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. | | Source | Neurosci Lett 2009 Oct 28. | | Abstract | Pharmacological and lesion studies have shown that histamine exerts inhibitory effects on morphine-induced reward-seeking behavior. The present study was designed to further investigate the involvement of endogenous histamine in morphine-induced reward-seeking behavior using histidine decarboxylase gene knockout (HDC-KO) mice. Conditioned place preference (CPP) was present in both wild-type (WT) and HDC-KO mice treated with 5 or 10mg/kg morphine. HDC-KO mice showed stronger morphine-induced CPP as compared with WT mice. Meanwhile, morphine significantly increased dopamine level in the VTA and NAc, especially in HDC-KO mice. However, the extinction of CPP is similar between WT and HDC-KO mice. Moreover, naloxone-precipitated withdrawal jumping was markedly decreased in HDC-KO mice. These results indicate that endogenous histamine inhibits the development, but not the extinction, of morphine-induced CPP and reduces morphine withdrawal sign, probably through modulating dopaminergic activity in the brain. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19879332 |
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