The STAR*D trial: revealing the need for better treatments. Psychiatric services (Washington, D.C.) [Psychiatr Serv] Journal article | | Title | The STAR*D trial: revealing the need for better treatments. | | Author(s) | Insel TR, Wang PS | | Institution | National Institute of Mental Health, Bethesda, MD 20892-9669, USA. insel@mail.nih.gov | | Source | Psychiatr Serv 2009 Nov; 60(11):1466-7. | | Abstract | STAR*D (Sequenced Treatment Alternatives to Relieve Depression) continues to stimulate debate. The landmark trial demonstrated the feasibility of large-scale, community-based studies conducted without pharmaceutical company support. The results provided insight into nonresponse to initial treatment with selective serotonin reuptake inhibitors and alternatives for second- and third-line treatment options and suggested opportunities for personalized approaches to depression care. However, initial and one-year remission rates (28% and 70%, respectively) suggest that important goals for treatment of this disabling disease remain out of reach and that the bar for antidepressants has been set far too low. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19880463 |
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