| Title | Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. | | Author(s) | Perez-Moreno CI, Couëtil LL, Pratt SM, Ochoa-Acuña HG, Raskin RE, Russell MA | | Institution | Animal Science (Perez-Moreno, Russell), Veterinary Clinical Sciences (Couëtil), Comparative Pathobiology (Pratt, Ochua-Acuña, Raskin), Purdue University, West Lafayette, Indiana 47906, USA. | | Source | Can Vet J 2009 Aug; 50(8):821-7. | | Abstract | The objective was to quantify the effect of furosemide and carbazochrome on exercise-induced pulmonary hemorrhage (EIPH) in Standardbred horses using red blood cell count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. Six healthy Standardbred horses with prior evidence of EIPH performed a standardized treadmill test 4 h after administration of placebo, furosemide, or furosemide-carbazochrome combination. Red blood cell (RBC) counts and hemoglobin concentrations were determined on the BAL fluid. The RBC count in BAL ranges were (2903-26 025 cells/muL), (45-24 060 cells/muL), and (905-3045 cells/muL) for placebo, furosemide, and furosemide-carbazochrome, respectively. Hemoglobin concentration ranges were (0.03-0.59 mg/mL), (0.01-0.55 mg/mL), and (0.007-0.16 mg/mL) for placebo, furosemide, and furosemide- carbazochrome groups, respectively. No significant differences were detected among treatments. However, there was great variability among horses, suggesting that a larger sample size or better selection of horses was needed. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19881919 |
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